Bleomycin/interleukin-12 electrochemogenetherapy for treating naturally occurring spontaneous neoplasms in dogs

On the basis of superior outcomes from electrochemogenetherapy (ECGT) compared with electrochemotherapy in mice, researchers from the  Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA,  determined the efficacy of ECGT applied to spontaneous canine neoplasms.

On the basis of superior outcomes from electrochemogenetherapy (ECGT) compared with electrochemotherapy in mice, researchers from the  Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana, USA,  determined the efficacy of ECGT applied to spontaneous canine neoplasms. Intralesional bleomycin (BLM) and feline interleukin-12 DNA injection combined with translesional electroporation resulted in complete cure of two recurrent World Health Organization stage T(2b)N(0)M(0) oral squamous cell carcinomas (SCCs) and one T(2)N(0)M(0) acanthomatous ameloblastoma. Three remaining dogs, which had no other treatment options, had partial responses to ECGT; one had mandibular T(3b)N(2b)M(1) melanoma with pulmonary and lymph node metastases; one had cubital T(3)N(0)M(1) histiocytic sarcoma with spleen metastases; and one had soft palate T(3)N(0)M(0) fibrosarcoma. The melanoma dog had decrease in the size of the primary tumour before recrudescence and euthanasia.

The histiocytic sarcoma dog had resolution of the primary tumour, but was euthanased because of metastases 4 months after the only treatment. The dog with T(3)N(0)M(0) fibrosarcoma had tumour regression with recrudescence.

Treatment was associated with minimal side effects and was easy to perform, was associated with repair of bone lysis in cured dogs, improved quality of life for dogs with partial responses and extended overall survival time.

ECGT seems to be a safe and resulted in complete responses in SCC and acanthomatous ameloblastoma.

Reed SD, Fulmer A, Buckholz J et al. Cancer Gene Ther 2010 Apr 23 [Epub ahead of print].

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