{"id":1046,"date":"2013-02-07T17:20:50","date_gmt":"2013-02-07T07:20:50","guid":{"rendered":"https:\/\/theveterinarian.com.au\/?p=1046"},"modified":"2013-03-01T17:23:02","modified_gmt":"2013-03-01T07:23:02","slug":"role-of-kcnq2-and-kcnq3-genes-in-juvenile-idiopathic-epilepsy-in-arabian-foals","status":"publish","type":"post","link":"https:\/\/theveterinarian.com.au\/?p=1046","title":{"rendered":"Role of KCNQ2 and KCNQ3 genes in juvenile idiopathic epilepsy in Arabian foals"},"content":{"rendered":"Juvenile idiopathic epilepsy (JIE) in Arabian foals resembles benign-familial neonatal convulsion (BFNC) syndrome, a rare idiopathic epilepsy of new-born humans. BFNC syndrome exhibits genetic heterogeneity, as has been hypothesised to occur in Arabian foals, and is known to be caused by mutations in the voltage-gated potassium channel subunit KCNQ2 and KCNQ3 genes.\r\n\r\nThe close phenotypic characteristics of both Arabian foals and children suggest these epileptic syndromes are caused by the same genetic disorder. In\u00a0horses, the KCNQ2 and KCNQ3 genes are located on the terminal region of chromosomes 22 and 9, respectively, essentially homologous to their location on chromosomes 20q13.3 and 8q24 in humans.\r\n\r\nGene trees for the KCNQ2 and KCNQ3 genes between\u00a0horses\u00a0and other mammals, particularly humans and mice, were constructed and compared to widely accepted mammalian phylogenetic trees. The KCNQ2 gene tree exhibited close clustering between\u00a0horses\u00a0and humans, relative to\u00a0horses\u00a0and mice, in contrast to the evolutionary trees of other mammals.\r\n\r\nDistance values between the horse\u00a0and human groups were lower as opposed to those found between the\u00a0horse\u00a0and mouse groups. The similarity between the\u00a0horse\u00a0and the human, especially for the KCNQ2 gene, where the majority of mutations causing BFNC have been found, supports the hypothesis of similar heritable and genetic patterns of the disease in both species and suggests that contrary to the classic mouse-model concept, humans may be a more suitable model for the study of JIE in Arabian foals.\r\n\r\nThe study is from the The Hebrew University of Jerusalem, Rehovot, Israel.\r\n\r\nLichter-Peled A,\u00a0Polani S,\u00a0Stanyon R,\u00a0et al. <em>Vet J<\/em>\u00a02012 Nov 20 [Epub ahead of print].\r\n\r\n&nbsp;","protected":false},"excerpt":{"rendered":"<p>Juvenile idiopathic epilepsy (JIE) in Arabian foals resembles benign-familial neonatal convulsion (BFNC) syndrome, a rare idiopathic epilepsy of new-born humans. BFNC syndrome exhibits genetic heterogeneity, as has been hypothesised to occur in Arabian foals, and is known to be caused by mutations in the voltage-gated potassium channel subunit KCNQ2 and KCNQ3 genes. The close phenotypic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[54,889,890,888,891,892,55],"class_list":["post-1046","post","type-post","status-publish","format-standard","hentry","category-abstracts","tag-abstracts-2","tag-arabian-foals","tag-hebrew-university-of-jerusalem","tag-jie","tag-kcnq2","tag-kcnq3","tag-research"],"rise-blocks_total_comments":0,"rise-blocks_categories":[{"term_id":3,"name":"Abstracts","slug":"abstracts","term_group":0,"term_taxonomy_id":3,"taxonomy":"category","description":"","parent":0,"count":237,"filter":"raw","cat_ID":3,"category_count":237,"category_description":"","cat_name":"Abstracts","category_nicename":"abstracts","category_parent":0}],"rise-blocks_excerpt":"Juvenile idiopathic epilepsy (JIE) in Arabian foals resembles benign-familial neonatal convulsion (BFNC) syndrome, a rare idiopathic epilepsy of new-born humans. BFNC syndrome exhibits genetic heterogeneity, as has been hypothesised to occur in Arabian foals, and is known to be caused by mutations in the voltage-gated potassium channel subunit KCNQ2 and KCNQ3 genes. The close phenotypic characteristics of both Arabian foals..","blog_post_layout_featured_media_urls":{"thumbnail":"","full":""},"categories_names":{"3":{"name":"Abstracts","link":"https:\/\/theveterinarian.com.au\/?cat=3"}},"tags_names":{"54":{"name":"abstracts","link":"https:\/\/theveterinarian.com.au\/?tag=abstracts-2"},"889":{"name":"Arabian foals","link":"https:\/\/theveterinarian.com.au\/?tag=arabian-foals"},"890":{"name":"Hebrew University of Jerusalem","link":"https:\/\/theveterinarian.com.au\/?tag=hebrew-university-of-jerusalem"},"888":{"name":"JIE","link":"https:\/\/theveterinarian.com.au\/?tag=jie"},"891":{"name":"KCNQ2","link":"https:\/\/theveterinarian.com.au\/?tag=kcnq2"},"892":{"name":"KCNQ3","link":"https:\/\/theveterinarian.com.au\/?tag=kcnq3"},"55":{"name":"research","link":"https:\/\/theveterinarian.com.au\/?tag=research"}},"comments_number":"0","wpmagazine_modules_lite_featured_media_urls":{"thumbnail":"","cvmm-medium":"","cvmm-medium-plus":"","cvmm-portrait":"","cvmm-medium-square":"","cvmm-large":"","cvmm-small":"","full":""},"_links":{"self":[{"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/posts\/1046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1046"}],"version-history":[{"count":1,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/posts\/1046\/revisions"}],"predecessor-version":[{"id":1047,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/posts\/1046\/revisions\/1047"}],"wp:attachment":[{"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}