{"id":1930,"date":"2015-04-30T12:28:09","date_gmt":"2015-04-30T02:28:09","guid":{"rendered":"https:\/\/theveterinarian.com.au\/?p=1930"},"modified":"2015-04-29T12:29:53","modified_gmt":"2015-04-29T02:29:53","slug":"abstracts-the-effects-of-diazepam-or-midazolam-on-the-dose-of-propofol-required-to-induce-anaesthesia-in-cats","status":"publish","type":"post","link":"https:\/\/theveterinarian.com.au\/?p=1930","title":{"rendered":"Abstracts: The effects of diazepam or midazolam on the dose of propofol required to induce anaesthesia in cats"},"content":{"rendered":"OBJECTIVES: Assess effects of benzodiazepine administration on the propofol dose required to induce anaesthesia in healthy cats, investigate differences between midazolam and diazepam, and determine an optimal benzodiazepine dose for co-induction.\r\n\r\nSTUDY DESIGN: Prospective, randomised, blinded, placebo-controlled clinical trial.\r\n\r\nANIMALS: Ninety client-owned cats (ASA I and II) with a median (interquartile range) body mass of 4.0 (3.4-4.9)\u00a0kg.\r\n\r\nMETHODS: All cats received 0.01\u00a0mg\u00a0kg-1\u00a0acepromazine and 0.2\u00a0mg\u00a0kg-1\u00a0methadone intravenously (IV). Fifteen minutes later, sedation was scored on a scale of 1-5, with 5 indicating greatest sedation. Propofol, 2\u00a0mg\u00a0kg-1\u00a0, administered IV, was followed by either midazolam or diazepam at 0.2, 0.3, 0.4 or 0.5\u00a0mg\u00a0kg-1\u00a0or saline 0.1\u00a0mL\u00a0kg-1\u00a0. Further propofol was administered until endotracheal intubation was possible. Patient signalment, sedation score, propofol dosage and adverse reactions were recorded.\r\n\r\nRESULTS: Midazolam and diazepam (all doses) significantly reduced the propofol dose required compared with saline (p\u00a0<\u00a00.001). There was no difference between midazolam and diazepam in propofol dose reduction (p\u00a0=\u00a00.488). All individual doses of midazolam reduced propofol requirement compared with saline (0.2\u00a0mg\u00a0kg-1\u00a0, p\u00a0=\u00a00.028; 0.3\u00a0mg\u00a0kg-1\u00a0, p\u00a0=\u00a00.006; 0.4\u00a0mg\u00a0kg-1\u00a0, p\u00a0<\u00a00.001; 0.5\u00a0mg\u00a0kg-1\u00a0, p\u00a0=\u00a00.009). Diazepam 0.2\u00a0mg\u00a0kg-1\u00a0did not reduce the propofol dose compared with saline (p\u00a0=\u00a00.087), but the remaining doses did (0.3\u00a0mg\u00a0kg-1\u00a0, p\u00a0=\u00a00.001; 0.4\u00a0mg\u00a0kg-1\u00a0, p\u00a0=\u00a00.032; 0.5\u00a0mg\u00a0kg-1\u00a0, p\u00a0=\u00a00.041). Cats with sedation scores of 3 required less propofol than cats with scores of 2 (p\u00a0=\u00a00.008). There was no difference between groups in adverse events.\r\n\r\nCONCLUSIONS AND CLINICAL RELEVANCE: Midazolam (0.2-0.5\u00a0mg\u00a0kg-1\u00a0) and diazepam (0.3-0.5\u00a0mg\u00a0kg-1\u00a0) administered IV after 2\u00a0mg\u00a0kg-1propofol significantly reduced the propofol dose required for tracheal intubation. \r\n\r\nThe study is from the Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, London, UK.\r\n\r\nRobinson R,\u00a0Borer-Weir K. <em>Vet Anaesth Analg<\/em>\u00a02015 Feb 14 [Epub ahead of print].","protected":false},"excerpt":{"rendered":"<p>OBJECTIVES: Assess effects of benzodiazepine administration on the propofol dose required to induce anaesthesia in healthy cats, investigate differences between midazolam and diazepam, and determine an optimal benzodiazepine dose for co-induction. STUDY DESIGN: Prospective, randomised, blinded, placebo-controlled clinical trial. ANIMALS: Ninety client-owned cats (ASA I and II) with a median (interquartile range) body mass of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[54,1569,165,1633,8,1634,1635,55,607],"class_list":["post-1930","post","type-post","status-publish","format-standard","hentry","category-abstracts","tag-abstracts-2","tag-anaesthesia","tag-cats","tag-diazepam","tag-feline","tag-midazolam","tag-propofol","tag-research","tag-royal-veterinary-college"],"rise-blocks_total_comments":0,"rise-blocks_categories":[{"term_id":3,"name":"Abstracts","slug":"abstracts","term_group":0,"term_taxonomy_id":3,"taxonomy":"category","description":"","parent":0,"count":237,"filter":"raw","cat_ID":3,"category_count":237,"category_description":"","cat_name":"Abstracts","category_nicename":"abstracts","category_parent":0}],"rise-blocks_excerpt":"OBJECTIVES: Assess effects of benzodiazepine administration on the propofol dose required to induce anaesthesia in healthy cats, investigate differences between midazolam and diazepam, and determine an optimal benzodiazepine dose for co-induction. STUDY DESIGN: Prospective, randomised, blinded, placebo-controlled clinical trial. ANIMALS: Ninety client-owned cats (ASA I and II) with a median (interquartile range) body mass of 4.0 (3.4-4.9)\u00a0kg. METHODS: All cats..","blog_post_layout_featured_media_urls":{"thumbnail":"","full":""},"categories_names":{"3":{"name":"Abstracts","link":"https:\/\/theveterinarian.com.au\/?cat=3"}},"tags_names":{"54":{"name":"abstracts","link":"https:\/\/theveterinarian.com.au\/?tag=abstracts-2"},"1569":{"name":"anaesthesia","link":"https:\/\/theveterinarian.com.au\/?tag=anaesthesia"},"165":{"name":"cats","link":"https:\/\/theveterinarian.com.au\/?tag=cats"},"1633":{"name":"diazepam","link":"https:\/\/theveterinarian.com.au\/?tag=diazepam"},"8":{"name":"feline","link":"https:\/\/theveterinarian.com.au\/?tag=feline"},"1634":{"name":"midazolam","link":"https:\/\/theveterinarian.com.au\/?tag=midazolam"},"1635":{"name":"propofol","link":"https:\/\/theveterinarian.com.au\/?tag=propofol"},"55":{"name":"research","link":"https:\/\/theveterinarian.com.au\/?tag=research"},"607":{"name":"Royal Veterinary College","link":"https:\/\/theveterinarian.com.au\/?tag=royal-veterinary-college"}},"comments_number":"0","wpmagazine_modules_lite_featured_media_urls":{"thumbnail":"","cvmm-medium":"","cvmm-medium-plus":"","cvmm-portrait":"","cvmm-medium-square":"","cvmm-large":"","cvmm-small":"","full":""},"_links":{"self":[{"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/posts\/1930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1930"}],"version-history":[{"count":1,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/posts\/1930\/revisions"}],"predecessor-version":[{"id":1931,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=\/wp\/v2\/posts\/1930\/revisions\/1931"}],"wp:attachment":[{"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1930"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/theveterinarian.com.au\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}