Study identifies effects of Chiari malformation on the canine brain

A UK study has identified the specific effect Chiari malformation has on the shape of a dog’s skull and brain, laying the groundwork for early screening. The prevalence of Chiari malformation (CM) has increased due to selective breeding of brachycephalic toy breeds including Cavalier King Charles Spaniels, Griffon Bruxellois, Affenpinschers and Chihuahuas. According to the […]

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Sequence analysis of the Equine ACTN3 Gene in Australian horse breeds

The sarcomeric α-actinins, encoded by the genes ACTN2 and ACTN3, are major structural components of the Z-line and have high sequence similarity. α-Actinin-2 is present in all skeletal muscle fibres, while α-actinin-3 has developed specialized expression in only type 2 (fast, glycolytic) fibres. A common single nucleotide polymorphism (SNP) in the human ACTN3 gene (R577X) […]

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Connective tissue disorders in domestic animals

Though soft tissue disorders have been recognized and described to some detail in several types of domestic animals and small mammals for some years, not much progress has been made in our understanding of the biochemical basis and pathogenesis of these diseases in animals. Ehlers-Danlos syndrome described in dogs already in 1943 and later in […]

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