Signs shown of genetic resistance to DFTD

Research by an international team of scientists, published at the end of August in the journal Nature Communications, shows two regions in the genomes of Tasmanian devils (Sarcophilus harrisii) appear to be evolving in response to the fatal facial tumour disease that has ravaged populations in the wild for almost 20 years. Evolutionary geneticist Andrew […]

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Reduced effect of Tasmanian devil facial tumour disease at the disease front

Pathogen-driven declines in animal populations are increasingly regarded as a major conservation issue. The Tasmanian devil (Sarcophilus harrisii) is threatened with extinction by devil facial tumor disease, a unique transmissible cancer. The disease is transmitted through direct transfer of tumor cells, which is possible because the genetic diversity of Tasmanian devils is low, particularly in the […]

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Allorecognition in the Tasmanian devil (Sarcophilus harrisii), an endangered marsupial species with limited genetic diversity

Tasmanian devils (Sarcophilus harrisii) are on the verge of extinction due to a transmissible cancer, devil facial tumour disease (DFTD). This tumour is an allograft that is transmitted between individuals without immune recognition of the tumour cells. The mechanism to explain this lack of immune recognition and acceptance is not well understood. It has been hypothesized […]

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Transmissible cancers in dogs and Tasmanian devils

The Tasmanian devil, the world’s largest marsupial carnivore, is facing possible extinction in the wild due to a transmissible facial cancer known as Tasmanian devil facial tumour disease (DFTD) (Figure 1). DFTD is spread when living cancer cells are spread between animals by biting. In DFTD, the living cancer cell itself is the infectious agent […]

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